Nicotine making me tired: Understanding the potential link between nicotine and fatigue. While nicotine is commonly known as a stimulant, it can also lead to feelings of tiredness in certain individuals. Nicotine’s impact on neurotransmitters and its effects on blood sugar levels can contribute to fatigue. Exploring healthier alternatives and managing nicotine intake can help mitigate the tiredness associated with nicotine consumption. Unlock valuable insights and learn more about vaping at openalltime.com.